痛風發病機制醫學資訊圖海報

{
  "type": "medical infographic poster",
  "topic": "gout pathogenesis and progression",
  "style": "ultra-detailed 3D biomedical illustration blended with vintage clinical editorial infographic design",
  "language": "Chinese with smaller English subtitles",
  "canvas": {
    "orientation": "vertical",
    "aspect_ratio": "1:2",
    "background": "warm off-white paper texture with subtle aging and clinical poster aesthetic"
  },
  "title_block": {
    "headline_cn": "痛風誕生的因果鏈",
    "headline_en": "THE CAUSAL CHAIN OF GOUT",
    "subheading": "A continuous chain from purines to crystals to inflammation, showing the full-body metabolic and immune pathway"
  },
  "central_visual": {
    "description": "半透明人體全身解剖圖（正面，從頭至腳，面部做柔和虛化處理）。清晰呈現骨骼、肌肉系統、主要血管、肝臟、腎臟、消化系統及下肢關節；發光代謝路徑與流向箭頭串聯各機制；圓形區域性剖面放大展示針狀尿酸鹽結晶、細胞浸潤、滑膜炎症與骨侵蝕破壞",
    "labels_count": 4,
    "labels": [
      "肝臟",
      "腎臟",
      "尿酸迴圈",
      "結晶沉積"
    ]
  },
  "top_process_strip": {
    "title_cn": "一條從分子到臨床的連續因果鏈",
    "title_en": "A CONTINUOUS CHAIN FROM MOLECULE TO CLINICAL DISEASE",
    "count": 6,
    "icons": [
      "代謝",
      "轉運",
      "結晶",
      "免疫",
      "炎症",
      "損傷"
    ]
  },
  "layout": {
    "sections": [
      {
        "number": "01",
        "title_cn": "嘌呤來源",
        "title_en": "Purine Sources",
        "position": "upper left",
        "items": [
          "外源性攝入: 紅肉、內臟、海鮮、啤酒",
          "內源性細胞代謝分解",
          "果糖負荷與含糖飲料"
        ]
      },
      {
        "number": "02",
        "title_cn": "尿酸生成",
        "title_en": "Uric Acid Production",
        "position": "left upper-mid",
        "items": [
          "嘌呤代謝途徑與黃嘌呤氧化酶 (XOD)",
          "次黃嘌呤至黃嘌呤再至尿酸生成"
        ]
      },
      {
        "number": "03",
        "title_cn": "腎臟與腸道排洩",
        "title_en": "Renal & Intestinal Excretion",
        "position": "left middle",
        "items": [
          "腎小管轉運體 (URAT1, GLUT9, ABCG2)",
          "腸道輔助排洩通道"
        ]
      },
      {
        "number": "04",
        "title_cn": "高尿酸血癥",
        "title_en": "Hyperuricemia",
        "position": "left lower-mid",
        "items": [
          "血尿酸過飽和生理閾值對比",
          "無症狀高尿酸血癥狀態"
        ]
      },
      {
        "number": "05",
        "title_cn": "結晶物理學",
        "title_en": "Crystal Physics",
        "position": "lower left-center",
        "items": [
          "單鈉尿酸鹽 (MSU) 微結晶成核",
          "低溫與酸性微環境誘導析出"
        ]
      },
      {
        "number": "06",
        "title_cn": "關節沉積與區域性環境",
        "title_en": "Joint Deposition & Local Environment",
        "position": "bottom left-center",
        "items": [
          "第一蹠趾關節 (MTP1) 好發解剖機制",
          "滑膜微迴圈與區域性軟骨表面沉積"
        ]
      },
      {
        "number": "07",
        "title_cn": "免疫炎症級聯",
        "title_en": "Immune Inflammatory Cascade",
        "position": "upper right",
        "items": [
          "巨噬細胞吞噬晶體與 NLRP3 炎症小體啟用",
          "IL-1β 釋放與中性粒細胞趨化募集"
        ]
      },
      {
        "number": "08",
        "title_cn": "急性痛風發作",
        "title_en": "Acute Gout Flare",
        "position": "right middle",
        "items": [
          "夜間突發紅、腫、熱、劇痛",
          "第一蹠趾關節微血管擴張與充血"
        ]
      },
      {
        "number": "09",
        "title_cn": "慢性結構損傷",
        "title_en": "Chronic Structural Damage",
        "position": "right lower-mid",
        "items": [
          "反覆發作誘發慢性滑膜炎",
          "軟骨剝脫與溶骨性骨侵蝕"
        ]
      },
      {
        "number": "10",
        "title_cn": "痛風石形成",
        "title_en": "Tophus Formation",
        "position": "right lower",
        "items": [
          "長期尿酸鹽重度蓄積與肉芽腫包繞",
          "指間關節及耳廓皮下痛風結節"
        ]
      },
      {
        "number": "11",
        "title_cn": "系統性病理影響",
        "title_en": "Beyond the Joint",
        "position": "lower right",
        "items": [
          "尿酸性腎結石與間質性腎病",
          "心血管及代謝綜合徵相關風險"
        ]
      },
      {
        "number": "12",
        "title_cn": "疼痛只是終末訊號",
        "title_en": "Pain Is the Final Signal",
        "position": "bottom full width",
        "items": [
          "代謝異常 → 高尿酸血癥 → 晶體沉積 → 炎症風暴 → 劇痛發作"
        ]
      }
    ]
  },
  "visual_details": {
    "arrows": "連線各病理節點的金褐色流向引導箭頭",
    "rendering": "超精細生物醫學解剖圖景，復古典雅臨床海報紙質觸感",
    "color_palette": "米白羊皮紙底色、深紅炎症對比、血管紅藍、尿酸結晶白色",
    "typography": "典雅宋體中文主標題，緊湊大寫英文副標題，圓角分塊清晰排版"
  },
  "negative_constraints": [
    "無扁平向量卡通風",
    "無霓虹賽博朋克光效",
    "無純黑背景"
  ]
}