Gout Pathophysiology Medical Infographic

{
  "type": "comprehensive medical infographic",
  "style": "highly detailed 3D medical illustration, clinical white background, clean modern typography",
  "header": {
    "title_cn": "[痛风诞生的因果链]",
    "title_en": "[THE CAUSAL CHAIN OF GOUT]",
    "subtitle": "Pain is not the beginning. Metabolic imbalance is.",
    "top_right_sequence": {
      "count": 6,
      "labels": [
        "Metabolism",
        "Transport",
        "Crystallization",
        "Immunity",
        "Inflammation",
        "Damage"
      ]
    }
  },
  "centerpiece": {
    "description": "[transparent anatomical human body showing liver, kidneys, and vascular system]",
    "details": "pathway highlighted in [glowing red] descending to the foot"
  },
  "layout": {
    "left_column": [
      {
        "id": "01",
        "title": "Purine Sources",
        "elements": 6,
        "labels": [
          "Red meat",
          "Organ meats",
          "Seafood",
          "Beer",
          "Endogenous",
          "Fructose"
        ]
      },
      {
        "id": "02",
        "title": "Uric Acid Production",
        "elements": 2,
        "labels": [
          "Chemical pathway",
          "Liver"
        ]
      },
      {
        "id": "03",
        "title": "Renal & Intestinal Excretion",
        "elements": 2,
        "labels": [
          "Kidney nephron",
          "Intestines"
        ]
      },
      {
        "id": "04",
        "title": "Hyperuricemia",
        "elements": 2,
        "labels": [
          "Blood vial",
          "Solubility graph"
        ]
      }
    ],
    "center_overlay": [
      {
        "id": "05",
        "title": "Crystal Physics",
        "elements": 3,
        "labels": [
          "Supersaturation beaker",
          "Precipitation beaker",
          "Molecular structure"
        ]
      },
      {
        "id": "06",
        "title": "Joint Deposition & Local Environment",
        "elements": 1,
        "labels": [
          "First MTP joint cross-section"
        ]
      }
    ],
    "right_column": [
      {
        "id": "07",
        "title": "Immune Inflammatory Cascade",
        "elements": 4,
        "labels": [
          "Macrophage",
          "Inflammasome",
          "Neutrophil",
          "Cytokines"
        ]
      },
      {
        "id": "08",
        "title": "Acute Gout Flare",
        "elements": 1,
        "labels": [
          "Inflamed foot"
        ]
      },
      {
        "id": "09",
        "title": "Chronic Structural Damage",
        "elements": 1,
        "labels": [
          "Bone erosion joint"
        ]
      },
      {
        "id": "10",
        "title": "Tophus Formation",
        "elements": 2,
        "labels": [
          "Hand tophi",
          "Foot tophi"
        ]
      },
      {
        "id": "11",
        "title": "Beyond the Joint",
        "elements": 2,
        "labels": [
          "Kidney stones",
          "Systemic burden"
        ]
      }
    ],
    "bottom_row": [
      {
        "id": "12",
        "title": "Pain Is the Final Signal",
        "elements": 7,
        "labels": [
          "Increased Purine",
          "Overproduction",
          "Reduced Excretion",
          "Hyperuricemia",
          "Crystal Formation",
          "Immune Activation",
          "Man in pain"
        ]
      }
    ]
  },
  "theme": "[gout and uric acid crystallization]"
}